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2 261 913

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IPC

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Application

2004100722/13, 2004-01-15

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Start date

2004-01-15

(22)

Actual filing date

2004-01-15

(45)

Published

2005-10-10

(72)

Inventor

Bairamashvili D.I.Vorob'Ev I.I.Gabibov A.G.Demin A.V.Miroshnikov A.I.Mart'Janov V.A.Ponomarenko N.A.Shuster A.M.

(73)

Holder

Institut Bioorganicheskoj Khimii Im.Akademikov M.M. Shemjakina I Ju.A. Ovchinnikova Rossijskoj Akademii NaukZakrytoe Aktsionernoe Obshchestvo

RECOMBINANT PLASMID DNA pES6-1 ENCODING HUMAN POLYPEPTIDE INTERFERON BETA-1b AND STRAIN Escherichia coli BDEES6 AS PRODUCER OF HUMAN RECOMBINANT INTERFERON BETA-1b Russian patent published in 2005 - IPC

Abstract RU 2261913 C1

FIELD: biotechnology, genetic and protein engineering.

SUBSTANCE: invention reports construction of plasmid DNA pES6-1 based on plasmid pET22b(+) and DNA fragment comprising a sequence of artificial gene encoding human interferon β-1b providing expression of human recombinant interferon β-1b. Also, the strain Escherichia coli BDEES6 (BL21(DE3)/pES6-1) as producer of human recombinant interferonβ-1b is prepared. Invention provides enhancing yield of human recombinant interferon β-1b. Invention can be used in medicine and pharmaceutical industry.

EFFECT: valuable biological and medicinal properties of strain.

2 cl, 2 dwg, 2 ex

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RU 2 261 913 C1

Authors

Bairamashvili D.I.

Vorob'Ev I.I.

Gabibov A.G.

Demin A.V.

Miroshnikov A.I.

Mart'Janov V.A.

Ponomarenko N.A.

Shuster A.M.

Dates

2005-10-10—Published

2004-01-15—Filed