FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to preparing a medicinal agent eliciting an anti-angiogenic effect and/or reducing penetrability of blood vessels. Agent represents derivative of quinazoline of the formula (I) 
, new compounds of the formula (II) 
, method for their preparing, intermediates substances used for their preparing and pharmaceutical composition comprising compounds of the formula (II) and a method for treatment of morbid states associated with angiogenesis and/or enhancing penetrability of blood vessels. Invention provides the enhanced effectiveness of treatment.
EFFECT: enhanced and valuable medicinal properties of agents.
37 cl, 20 tbl, 326 ex
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|---|---|---|---|
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