METHOD FOR DETECTION OF ALPHA-2-MACROGLOBULIN MOLECULE PATHOLOGY IN PATIENTS WITH CRANIAL TRAUMA Russian patent published in 2005 - IPC

FIELD: medicine, neurosurgery, neuropathology, neurochemistry, physiology.

SUBSTANCE: method for detection of pathology of alpha-2-macroglobulin pathology in patients with cranial trauma involves simultaneous quantitative determination of alpha-2-macroglobulin content in cerebrospinal fluid of patient by electophoretic study and investigation of inhibitory enzymatic activity of alpha-2-macroglobulin with low-molecular synthetic N-benzoyl-DL-arginine-p-nitroanilide as a substrate. Pathology in alpha-2-macroglobulin in the patient with cranial trauma is detected in the case for presence of protein by electrophoretic method and by absence the inhibitory enzymatic activity of this protein. Using this method provides enhancing the precision in detection of alpha-2-macroglobulin pathology that promotes to well-timed prescribing the adequate therapy for patients with cranial trauma.

EFFECT: improved detecting method.

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