ANTHRANILIC ACID ORTHO-SUBSTITUTED AMIDES AND THEIR USING AS MEDICINAL AGENTS Russian patent published in 2005 - IPC

FIELD: organic chemistry, biochemistry, pharmacy.

SUBSTANCE: invention relates to compounds of the general formula (I):

wherein R¹ represents the following groups:

wherein * means the addition point; R⁴ means fluorine, chlorine, bromine atom, -CF₃, -N=C, -CH₃, -OCF₃ or -CH₂OH; R⁵ means chlorine, bromine atom or -OCH₃; R⁶ means -CH₃ or chlorine atom; R⁷ means -CH₃ or chlorine atom; R⁸ means -CH₃, fluorine, chlorine atom or -CF₃; R² represents pyridyl or group:

or ; R³ represents hydrogen or fluorine atom, and their tautomers, E-isomers or Z-isomers, racemates, enantiomers and salts also that are inhibitors of activity of tyrosine kinase KDR and FLT. Also, invention describes medicinal agents comprising the claimed compounds and designated for treatment of diseases associated with inhibition of activity of kinase KDR and FLT.

EFFECT: valuable biochemical and medicinal properties of compounds.

6 cl, 1 tbl, 30 ex