SUBSTITUTED AMIDES OF BENZOIC ACID AND PHARMACEUTICAL PREPARATION CONTAINING THEM Russian patent published in 2009 - IPC C07D213/56 C07D217/22 C07D401/12 C07C235/42 A61K31/16 A61K31/44 A61P19/02 A61P7/02 A61P27/06 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to substituted amides of benzoic acid of formula (I), their isomers and salts as inhibitors of KDR and FLT tyrosine kinase, as well as to medication based on them. Compounds can find application as medications for treating diseases caused by persisting angiogenesis. In general formula (I) (I), A represents group =NH, W represents oxygen, Z represents bond or branched or non-branched C₁-C₁₂alkyl, R¹ represents branched or non-branched C₁-C₆alkyl or optionally single- or multi-substituted with C₁-C₆alkyl C₃-C₁₀cycloalkyl, or unsubstituted or optionally single- or multisubstituted with halogen, C₁-C₆alkyl, single- or multisubstituted with halogen C₁-C₆alkyl phenyl, naphtyl, quinolyl, isochinolyl, indenyl, R² and R³represent hydrogen, OH-group or group XR¹¹, X represents C₂-C₆alkyl, C₂-C₆alkenyl or C₂-C₆alkinyl, R¹¹ represents unsubstituted or optionally single- or multisubstituted with halogen, C₁-C₆alkoxygroup or hydroxy group phenyl ot pyridyl, R⁴, R⁵, R⁶ and R⁷represent hydrogen, R² and R³ simultaneously do not represent hydrogen, and if R⁷ represents OH-group, R³ does not represent hydrogen, and if R³ represents OH-group, R² does not represent hydrogen.

EFFECT: obtaining compounds which can be applied as medications for treating diseases caused by persisting angiogenesis.

3 cl, 160 ex