SUBSTITUTED 2-ARYL-3-(HETEROARYL)IMIDAZO[1,2-A]-PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF AND ASSOCIATED METHODS Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel substituted 2-aryl-3-(heteroaryl)imidazo[1,2-a]-pyrimidines of the formula (I):

or to their pharmaceutically acceptable salts wherein: (a) R₁ is taken among the group consisting of -NH₂, C_1-5-alkylamino-, di-C_1-5-alkylamino-, phenylmethylamino-group; (b) Y is taken among the group consisting of hydrogen atom (H), halogen atom, piperidine, OR₄, SR₄, -SO₂CH₃, NHR₄ and NR₄R₅ wherein R₄ and R₅ are taken independently among hydrogen atom (H), α-alkylphenyl-C_1-5-alkyl, linear or branched alkyl substituted optionally with C_3-5-carbocycle, phenyl or substituted phenyl wherein indicated phenyl can be substituted with one or some substituted taken among C_1-5-alkoxy-group; (c) R₂ represents from one to five members taken independently among the group including hydrogen atom (H), halogen atom, trifluoromethyl; (d) R₃ represents hydrogen atom (H), or radicals R₃ taken in common form aromatic ring; (e) X represents nitrogen atom (N) or -CH. Also, invention relates to methods for preparing indicated compounds and to a method for treatment based on these compounds. Invention provides preparing novel compounds that can be used in relief states by reducing the level of inflammatory cytokines, for example, the indicated state represents proliferative (rheumatic) arthritis.

EFFECT: valuable medicinal properties of compounds and compositions.

40 cl, 1 tbl, 4 ex