SUBSTITUTED 3-PYRIDYL-4-ARYLPYRROLES AND THERAPEUTIC AND PROPHYLACTIC METHODS ASSOCIATED WITH THEM Russian patent published in 2004 - IPC

Abstract RU 2238940 C2

FIELD: organic chemistry, medicine.

SUBSTANCE: invention relates to new substituted 3-pyridyl-4-arylpyrroles of the formula (I):

wherein R₁ means hydrogen atom (H), (C₁-C₅)-alkyl, (C₁-C₅)-alkylamino-group, amino-group which are substituted with dimethyl, N-containing (C₁-C₅)-alkylheterocycle taken among methyl-substituted piperidine, morpholine, pyrrolidine, thiazine, methyl-substituted pyrrole. Phenyl, phenyl substituted with one or more (C₁-C₅)-alkyl, amino-group, NHAc, Nitro-group, nitrile and sulfone and pyridine; R₂ means hydrogen atom (H), (CH₂)₃OH, unsubstituted (C₁-C₅)-alkylphenyl and morpholine; R₃ represents one or more substituents taken independently among the group consisting of hydrogen, halogen atom, methoxy-group, trifluoromethyl, hydroxy-group, dimethylamino-group; X represents either carbon atom © or nitrogen atom (N), or its pharmaceutically acceptable salt. Compound of the formula (I) inhibit producing TNF-α that allows their using in pharmaceutical composition for treatment of inflammatory disorders mediated by inhibition in producing TNF-α and/or activity of p38.

EFFECT: valuable medicinal properties of compounds.

19 cl, 6 sch, 5 tbl

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RU 2 238 940 C2

Authors

Bullington Dzhejms

Dates

2004-10-27—Published

2000-04-28—Filed