SUBSTITUTED IMIDAZOLES, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHODS FOR TREATMENT OF CYTOKINE-MEDIATED DISEASES Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to derivatives of imidazole of the formula (I) wherein R₁ means phenyl, phenyl substituted with halogen atom or pyridyl; R₂ means phenyl, phenyl substituted with halogen atom or pyridyl; R₃ means hydrogen atom, 2-(trimethylsilyl)ethoxymethyl, phenyl-C_1-5-alkyl; R₄ means -(A)-(CH₂)_q-X wherein: A means vinylene, ethynylene or wherein R⁵ means hydrogen atom; q = from 0 to 5; X is taken among group consisting of hydrogen atom, hydroxy-group, vinyl, substituted vinyl (wherein one or more substituents are taken among group consisting of fluorine, bromine, chlorine and iodine atom), ethynyl, substituted ethynyl (wherein substituents are taken among one or more member of group consisting of fluorine, bromine, chlorine and iodine atom), C_1-5-alkyl, C_3-7-cycloalkyl, C_1-5-alkoxy-group, phthalimidooxy-group, phenyl, phenyl substituted with C_1-5-alkoxy-group, nitrile, phenylcarbonyloxy-group, C_1-5-alkylthio-group. Invention describes also pharmaceutical composition based on these compounds and methods for treatment of cytokine-mediated diseases. Invention provides preparing new compounds eliciting valuable biological properties. EFFECT: improved treatment method, valuable medicinal properties of compounds. 32 cl, 4 tbl, 17 ex