HETEROCYCLIC COMPOUNDS Russian patent published in 2010 - IPC C07D471/04 C07D498/04 C07D491/04 C07D513/04 C07D495/04 C07D487/04 

FIELD: chemistry.

SUBSTANCE: invention relates to new compounds of formula I. In general formula I A is C or N; B, D and E independently represent CR⁴, NR⁵, N, O or S; and a ring containing groups A, B, D, E, selected from thienyl, furan, imidazole, oxazole, isothiazole, thiazole, pyrrol, pyrazole; provided that: b) when A is N, not any of B, D, E can be O or S; and c) when A is C, B is CR⁴ and one of D or E is N or NR⁵, when any of D or E cannot be NR⁵ or N; G is N or C; R¹ represents one or more substitutes selected from H, R^a halogen, -OH and -OR^a; R² represents one or more substitutes selected from H, halogen and C_1-6-alkyl, and also one of substitutes R² can be -OR^b' , -NR^b' R^b', -SR^b', -SOR^b', -SO₂R^b', -SO₂NR^b' R^b'; R³ is H, or Cy, selected from phenyl optionally substituted with one or more substitutes selected from R^c , where R^c independently represents halogen, -OR^g', where R^g' independently represents a R^g group, where R^g is C_1-6-alkyl; each R⁴ independently represents H, R^e, halogen, -COR^e', -CO₂R^e', -CONR^e'R^e', -NR^e'R^e'; R⁵ independently represents H, R^e, -COR^e, -CONR^eR^e, -SOR^e or -SO₂R^e; each R^a independently represents C_1-6-alkyl or halogen- C_1-6-alkyl; each R independently represents C_1-6-alkyl optionally substituted with one or more substitutes selected from R^d and R^f; each R^b' independently represents H or R^b; each R^c independently represents halogen, -OR^g', -CONR^g'R^g', -NR^g'R^g'; R^d is Cy optionally substituted with one or more R^f substitutes; each R^c independently represents C_1-6-alkyl optionally substituted with one or more substitutes selected from R^c and Cy*, or R^e is Cy, where any of the groups Cy or Cy* can optionally be substituted with one or more substitutes selected from R^c and R^g ; each R^e' independently represents H or R^e; each R^f independently represents a halogen, -OR^h', -CO₂R^h; each R^g independently represents R^d or C_1-6-alkyl optionally substituted with one or more substitutes selected from R^d and R^f; each R^g' independently represents H or R^g; each R^h independently represents C_1-6-alkyl, halogen-C_1-6-alkyl or hydroxy- C_1-6-alkyl; each R^h' independently represents H or R^h; and Cy or Cy* given in definitions above is a partially saturated, saturated or aromatic 3-7-member monocyclic carbocyclic ring which optionally contains 1-2 heteroatoms selected from N and O, and where the ring or rings can be bonded to the remaining part of the molecule through a carbon or nitrogen atom.

EFFECT: obtaining formula I compounds with p38-kinase inhibitory properties which can be used in making drugs for treating such diseases as tumour immune and autoimmune diseases etc.

21 cl, 10 dwg, 8 tbl, 57 ex