FIELD: organic chemistry, medicine, biochemistry, pharmacy.
SUBSTANCE: invention relates to derivatives of α-aminohydroxamic acid of the formula (I):
wherein R1 means hydrogen atom, (lower)-alkyl or phenyl-(lower)-alkyl; R2 means hydrogen atom or (lower)-alkyl; R3 means (lower)-alkyl or phenyl; A means (C1-C3)-alkylene; q = 1-5; R means (C2-C7)-alkyl, (C3-C7)-alkenyl, (C3-C7)-alkynyl, and its pharmaceutically acceptable salts. These compounds are inhibitors of MMP and first of all inhibitors of MMP2 and can be used in treatment of inflammatory states, proliferative arthritis, osteoarthritis, oncological and pulmonary diseases. Also, invention describes a method for preparing compounds and a pharmaceutical composition.
EFFECT: improved preparing method, valuable medicinal properties of compounds and composition.
18 cl, 1 tbl, 87 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND APPLICATION METHODS THEREOF | 2007 |
|
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