METHOD FOR PREDICTING 5 YEARS LONG SURVIVAL PERIOD WITHOUT PROGRESS IN THE CASES OF URINARY BLADDER CARCINOMA AFTER RADICAL SURGICAL TREATMENT Russian patent published in 2005 - IPC

FIELD: medicine.

SUBSTANCE: method involves determining invasion depth, cancer cell differentiation degree in neoplasm bioptate, staining the bioptate with silver nitrate solution, determining mean number of nucleoli M_n in 100 nuclei adjacent to each other and standard deviation of argentophilic granules in the nucleoli SD_ag. 5 years long survival without cancer progress at any invasion depth is calculated as S=2.289*M_n+0.219*SD_ag+0.998*pT-0.102*G, where pT is the urinary bladder carcinoma cell invasion depth (pT_a=1, pT₁=2, pT₂=3, pT₃=4, pT₄=5); G is the urinary bladder carcinoma cell differentiation degree (G₁=1, G₂=2, G₃=3). S values being ≤6.95, 5 years long survival without cancer progress is to be predicted. Nucleoli distribution variation coefficient CV_n and argentophilic granules distribution excess E_ag in nucleoli are additionally determined. The 5 years long survival without cancer progress S_pr=0.1727*CV_n+0.3276* E_ag. S_pr value being >7.75, 5 years long survival is predicted.

EFFECT: high accuracy of the method.