METHODS FOR PREPARING DERIVATIVES OF 2-AMINOMETHYLPYRIDINE AND 2-CYANOPYRIDINE Russian patent published in 2005 - IPC

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to the improved methods for preparing compounds of the formulae (I) and (II) or their salts wherein X represents halogen atom; Y represents halogen atom, halogenalkyl, alkoxycarbonyl or alkylsulfonyl; n = 0-3. Method for preparing compound of the formula (I) involves catalytic hydrogenation of compound of the formula (II) in the presence of a catalyst, such as palladium in solvent medium at temperature from 0°C to 60°C. Method provides preparing the end compounds with high yields (95-97%) and high purity degree due to minimization of by-side dehalogenation reaction of the parent reagents. Method for preparing compound of the formula (II) involves treatment of the corresponding derivative of 2-fluoro-derivative with the cyanide source in the presence of a catalyst, such as tetraalkyl ammonium salt in an aqueous solvent or without solvent at temperature from 10°C to 60°C. Method provides preparing the end compounds with high yields (80-90%), high purity (98%) at moderate temperatures.

EFFECT: improved preparing methods.

23 cl, 3 ex