PHARMACEUTICAL COMPOSITION, METHOD FOR ITS PREPARING AND USING Russian patent published in 2007 - IPC C07D401/04 C07D495/04 C07D401/14 C07D405/14 C07D405/12 C07D413/08 C07D413/14 C07D487/04 A61K31/40 A61K31/4025 A61K31/407 A61K31/403 A61K31/4545 A61K31/519 A61K31/4725 A61K31/497 A61K31/554 A61P5/38 A61P5/40 A61P5/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to pharmaceutical compositions possessing inhibitory effect with respect to MC2R-receptors, for preparing medicinal preparations as tablets, granules, capsules, suspensions, solutions or injections placed into pharmaceutically acceptable package. As active substance the composition comprises azaheterocyclic compound of general formulas (1.1.1) , (1.2.1) or (1.3.1) , wherein R¹ in the general formula (1.1.1) represents substituted alkyl, aryl, heteroaryl, heterocyclyl, or R¹ in the general formula (1.2.1) represents a substitute of amino-group chosen from hydrogen atom or possibly substituted lower alkyl or lower acyl; each R², R³ and R⁴ represents independently of one another a substitute of cyclic system chosen from hydrogen atom, azaheterocyclyl, possibly substituted lower alkyl, possibly substituted hydroxy-group, carboxy-group, cycloalkyl; or R³ and R⁴ in common with carbon atoms to which they are bound form azaheterocycle, or R¹ in common with nitrogen atom to which it is bound, and R³ and R⁴ in common with carbon atoms to which they are bound form azaheterocycle through R¹, R³ and R⁴; R¹⁸ and R¹⁹ represent independently of one another substitutes of amino-group chosen from hydrogen atom or lower alkyl substituted with azaheterocycle as their racemates, optically active isomers or their pharmaceutically acceptable salts and/or hydrates; R²⁰ and R²¹ in common with nitrogen atom to which they are bound form possibly substituted azaheterocycle. Also, invention relates to a method for preparing a pharmaceutical composition and using compounds and compositions for preparing medicinal preparations and for treatment or prophylaxis of diseases associated with enhanced activation of adrenocorticotropic hormone for compounds of general formulas (1.1.1), (1.2.1) and (1.3.1), and for using compounds for experimental investigations of indicated processes in vitro or in vivo also.

EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions, improved preparing method.

15 cl, 1 dwg, 4 tbl, 5 ex