FIELD: medicine, pharmacy.
SUBSTANCE: medicinal formulation possessing an anti-vomiting effect consists of core and envelope dissolving in stomach. Core comprises the following components, wt.-%: domperidone, 2.0-40.0; starch, 7.0-18.5; sodium dodecyl sulfate, 0.1-0.3; polyvinylpyrrolidone, 1.5-4.0; calcium stearate, 0.5-1.2; aerosil, 1.0-3.0; lactose, 49.9-71.0. Envelope comprises the following components, wt.-%: hydroxypropylmethylcellulose, 50.0-70.0; Twin-80, 15.0-25.0, and titanium dioxide, 15.0-25.0. Also, invention describes a method for preparing the medicinal formulation by wet granulation followed by tableting and applying a coating from an aqueous suspension. Deviation of separate tablets by mass is 4.5-5.5%. Tablets possess sufficient strength for qualitative applying the envelope. Decomposition time of tablets is 6-7 min. From 97.8% to 98.4% of domperidone is released from tablet to solution for 45 min.
EFFECT: improved and valuable pharmaceutical properties of medicinal formulation.
3 cl, 1 tbl
