FIELD: medicine.
SUBSTANCE: method involves inoculating immunomodulating preparation under study to immunocompetent mice in human dose calculated per 1 kg of animal weight in volume of 0.2-0.5 ml. Next, test strain is introduced in lethal dose. The animals are observed during 21 days. Mean survival period is calculated in case and control groups. Longer survival period being observed in the case group, when compared to control group, the immunomodulating preparation is considered to possess protection power. Mice having immunosuppression induced by Tahin virus are used as case group. Mean life or their survival period being the same or higher in case group when compared to the control one, the immunomodulating preparation is considered to possess protection power.
EFFECT: high accuracy of model; wide range of applications in studying protective action.
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