FIELD: medicine.
SUBSTANCE: invention refers to medicine, particularly to microbiology and immunology and can be used for immunoprophylaxis of pseudocholera. The method involves antigen pretreatment to mice followed by infection and estimating level of protectivity. Antigens Burkholderia pseudomallei are chosen of superficial antigenic fractions: D, C, F, J, H. Herewith the antigen solution in amount 1.5 ml is mixed with phosphatidyl choline approximately 40 mg and cholesterol in the ratio 7:3 to produce liposomes.
EFFECT: invention allows improving survival rate of laboratory animals infected with pseudocholera owing to higher protectivity of pseudocholera antigens entrapped in liposomes.
2 cl, 4 tbl, 2 ex
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| METHOD FOR INCREASING ANTIGEN IMMUNOGENECITY OF B. pseudomallei ANTIGENS IN EXPERIMENTAL MELIOIDOSIS | 2012 |
|
RU2483752C1 |
| METHOD OF MELIOIDOZE ANTIGEN ESTIMATE FOR PROTECTIVITY LEVEL | 2007 |
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RU2354400C1 |
| METHOD FOR INCREASE OF MELIOIDOSIS ANTIGENS PROTECTIVITY BY CYTOKINES | 2008 |
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RU2376031C1 |
| METHOD FOR DETERMINING BURKHOLDERIA MALLEI CAPSULAR ANTIGEN IMMUNOGENICITY LEVEL | 2005 |
|
RU2293993C1 |
| METHOD OF PREPARING PROTECTIVE GLYCOPROTEIN OF MELIOIDOSIS PATHOGEN | 1996 |
|
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| METHOD OF IMPROVING EFFICIENCY OF EMERGENCY PREVENTION OF EXPERIMENTAL MELIOIDOSIS | 2016 |
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RU2618425C1 |
| ANTIGEN-CONTAINING LIPOSOME PREPARATION PROCESS | 2008 |
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RU2356538C1 |
| METHOD OF SPECIFIC PROPHYLAXIS OF MELIODOSIS | 1992 |
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RU2065308C1 |
| METHOD FOR PREPARING MELIODOSIS PATHOGEN CAPSULE ANTIGEN ELICITING ANTI-PHAGOCYTIC ACTIVITY | 2003 |
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RU2255762C2 |
| METHOD FOR MODELING PULMONARY MELIOIDOSIS | 1999 |
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RU2157538C1 |
