FIELD: medicine, experimental physiology.
SUBSTANCE: the present innovation deals with studying the flow of myocardial infarction at the impact of cardioprotector preparation. For this purpose, infarction in rats should be induced due to applying ligature onto posterior branch of right-hand coronary artery. Moreover, as a cardioprotector remedy one should apply L-arginine which should be once introduced intravenously at the dosage of 50 or 100 mg/kg about 20-30 min before applying a ligature. The innovation provides the chance to study mechanisms to prevent the development of myocardial infarction complications with L-arginine at maximal similarity of infarction model to clinical conditions of human infarction development.
EFFECT: higher efficiency.
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