METHOD OF ACETYLSALICYLIC ACID BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY Russian patent published in 2009 - IPC A61K31/185 A61K31/616 A61P9/00 

Abstract RU 2364392 C1

FIELD: medicine.

SUBSTANCE: invention concerns medicine, particularly experimental cardiopharmacology and can be used for correction of endothelial dysfunction that is ensured by simulation thereof in experiment by daily intraperitoneal introduction to Wistar male rats within 7 days of N-nitro-L-arginine methyl ester in a dose 25 mg/kg. Degree of dysfunction development is estimated by relation of endothelium-independent to endothelium-dependent vasodilation. Correction of dysfunction is carried out by intragastric introduction of acetylsalicylic acid in a dose 8.6 mg/kg once a day.

EFFECT: method allows estimating correction of endothelial dysfunction in dynamics in specific simulation environment.

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RU 2 364 392 C1

Authors

Pokrovskij Mikhail Vladimirovich

Pokrovskaja Tat'Jana Grigor'Evna

Artjushkova Elena Borisovna

Tsepelev Vasilij Jur'Evich

Belous Aleksandr Sergeevich

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Gladchenko Mikhail Petrovich

Gureev Vladimir Vladimirovich

Babko Anna Vladimirovna

Novikov Oleg Olegovich

Novikova Marina Jur'Evna

Kochkarov Vladimir Iskhakovich

Danilenko Ljudmila Mikhajlovna

Tsybul'Skij Igor' Valer'Evich

Khardikova Elena Mikhajlovna

Luchkina Elena Vadimovna

Ershov Il'Ja Nikolaevich

Dates

2009-08-20Published

2008-03-19Filed