FIELD: medicine.
SUBSTANCE: invention concerns medicine, particularly experimental cardiology and pharmacology, and can be used for correction of endothelial dysfunction that is ensured by simulation of endothelial dysfunction in experiment by daily intraperitoneal introduction to Wistar male rats of N-nitro-L-arginine methyl ester in a dose 25 mg/kg, within 7 days. Correction of dysfunction is carried out daily within 7 days by intragastric introduction of Clopidogrel in a dose 6.5 mg/kg. Degree of dysfunction development is determined by relation of endothelium-independent to endothelium-dependent vasodilation.
EFFECT: method provides correction of endothelial dysfunction in specific simulation environment.
2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION BY COMBINATION OF TRIMETAZIDINE AND L-ARGININE IN L-NAME-INDUCED NITROGEN OXIDE DEFICIENCY | 2009 |
|
RU2421822C2 |
| METHOD OF ACETYLSALICYLIC ACID BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364392C1 |
| METHOD FOR RECOMBINANT ERYTHROPOIETIN CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY | 2009 |
|
RU2409873C1 |
| METHOD OF LAMOTRIGINE CORRECTION OF ENDOTHELIAL DYSFUNCTION ASSOCIATED WITH L-NAME INDUCED NITROGEN OXIDE DEFICIENCY | 2008 |
|
RU2367421C1 |
| METHOD OF PICAMILONUM-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364393C1 |
| METHOD OF TADALAFIL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364395C1 |
| METHOD OF CORRECTION OF ENDOTHELIAL DYSFUNCTION BY PHOSPHOGLIV PREPARATION AT L-NAME INDUCED DEFICIENCY OF NITROGEN OXIDE | 2008 |
|
RU2359668C1 |
| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH PREPARATION PHOSPHOGLIV LYOPHILIZATE IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY | 2008 |
|
RU2372078C1 |
| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH SOLVENT MIXTURE OF HOMEOPATHIC DILUTIONS OF POLYCLONAL RABBIT ANTIBODIES TO HUMAN ENDOTHELIAL NITROGEN OXIDE SYNTHASE C12, C30, C200 | 2006 |
|
RU2306953C1 |
| METHOD OF CORRECTING ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF LOZARTAN AND RAZVERATROL IN CASES OF LONAME-INDUCED NITROGEN MONOXIDE DEFICIENCY | 2005 |
|
RU2306924C1 |
