FIELD: biochemistry, in particular preparation of chloro-substituted nitrophenol.
SUBSTANCE: claimed method includes oxidative chlorination of 4-nitrophenol with mixture of hydrochloric acid and 19-33 % hydrogen peroxide in 30-60 % sulfuric acid medium. Molar ratio of 4-nitrophenol/oxiding agent is 1:1. Obtained product precipitate is filtered and washed with cold water. Preparations of present invention are useful as active ingredient for antifungal drugs in skin lesions.
EFFECT: improved method; increased yield of target product.
1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF OBTAINING 2-CHLORO-4-AMINOPHENOL | 2023 |
|
RU2816355C1 |
| METHOD OF SYNTHESIS OF 2-CHLORO-4-NITROPHENOL | 1993 |
|
RU2046794C1 |
| METHOD FOR PRODUCTION OF 4-NITROPHENOL | 1995 |
|
RU2076095C1 |
| ANTIFUNGAL PREPARATION | 2002 |
|
RU2248202C2 |
| METHOD FOR PRODUCTION OF 2-CHLOR-4-NITROPHENOL | 2021 |
|
RU2792890C2 |
| METHOD OF PREPARING 5-NITRO-8-HYDROXYQUINOLINE | 1999 |
|
RU2154636C1 |
| METHOD FOR PREPARING 2-CHLORO-4-NITROPHENOL | 2004 |
|
RU2268877C1 |
| METHOD OF OBTAINING AMINOPHENOLS | 2022 |
|
RU2800099C1 |
| 0 |
|
SU1781207A1 | |
| METHOD OF NITROBENZENE SYNTHESIS | 1992 |
|
RU2042661C1 |
