FIELD: organic chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, specifically to a method for the production of 2-chlor-4-nitrophenol used for the treatment of fungal skin lesions. According to the proposed method, 2-chlor-4-nitrophenol is obtained by chlorination of 4-nitrophenol, while t-BuOCl is used as a chlorinating agent, the reaction is carried out in the presence of catalysts selected from FeBr2, Fe(C5H5)2, FeCl2⋅4H2O, FeCl3⋅6H2O, at 20°C for 0.5-5 h, at a molar ratio of [catalyst] : [4-nitrophenol] : [t-BuOCl] = 0.1-1:100:100-120.
EFFECT: proposed method allows for simplification of a technology and reduction in cost price of the production of 2-chlor-4-nitrophenol, as well as reduction in amount of waste.
1 cl, 1 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PRODUCING ALKYL ETHERS OF METOXYBENZOIC ACIDS | 2016 |
|
RU2640206C1 |
| METHOD OF SYNTHESIS OF 2-CHLORO-4-NITROPHENOL | 1993 |
|
RU2046794C1 |
| METHOD OF PRODUCING 1,3-DICHLOROADAMANTANE | 2011 |
|
RU2459797C1 |
| METHOD OF PRODUCING 1-CHLOROADAMANTANE | 2011 |
|
RU2486169C2 |
| METHOD FOR PREPARING 2-CHLORO-4-NITROPHENOL | 2004 |
|
RU2268877C1 |
| METHOD FOR SUBSTITUTED QUINOLINES PRODUCTION FROM ANILINE, 1,2-DIOLS AND CCL4 UNDER IRON CATALYSTS | 2015 |
|
RU2614251C2 |
| METHOD OF PRODUCING MONO- AND DIFLUORO BENZYL CHLORIDES | 2015 |
|
RU2596872C1 |
| METHOD OF OBTAINING 2-CHLORO-4-AMINOPHENOL | 2023 |
|
RU2816355C1 |
| METHOD FOR PRODUCTION OF 2-CHLORO-4-NITROPHENOL | 2003 |
|
RU2269511C2 |
| METHOD FOR PREPARING 3-DICHLOROMETHYLPYRIDINE | 2006 |
|
RU2316547C1 |
