FIELD: organic chemistry, heterocyclic compounds, medicine.
SUBSTANCE: invention relates to dihydropyrimidine compounds of the formula (I*): 
their enantiomers, diastereoisomers and pharmaceutically acceptable salts wherein X1, X2 and X3 in common with atoms to which they are added form ring of the formula: 
or 
; R1 represents hydrogen atom; R2, R3*, R4, R5, R6 and R7 have values given in cl. 1 of the invention claim. Also, invention relates to separate dihydropyrimidine compounds. Proposed compounds are inhibitors of calcium channel function being especially inhibitors of Kv1 subfamily of potential-overlapping K+-channels and especially inhibitors of Kv 1.5 that associated with super-rapid activating delayed cleaning K+-flow of Ikur and can be used in treatment of arrhythmia and Ikur-associated diseases.
EFFECT: valuable medicinal properties of compounds.
15 cl, 589 ex
| Title | Year | Author | Number |
|---|---|---|---|
| BICYCLIC DIHYDROPYRIMIDINECARBOXAMIDE DERIVATIVES AS RHO-KINASE INHIBITORS | 2017 |
|
RU2778478C2 |
| SUBSTITUTED PYRAZOLOPYRIMIDINES AS GLUCOCEREBROSIDASE ACTIVATORS | 2011 |
|
RU2603637C2 |
| PYRAZOLO[3,4-b]PURIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITION (VERSIONS), APPLICATION (VERSIONS), COMBINATION (VERSIONS) | 2003 |
|
RU2357967C2 |
| CONDENSED TRIAZOLAMINES AS P2X7 MODULATORS | 2010 |
|
RU2533122C2 |
| COMPOUNDS AND COMPOSITIONS AS CANNABINOID RECEPTOR 1 INHIBITORS | 2005 |
|
RU2431635C2 |
| N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDE COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS | 2015 |
|
RU2821520C2 |
| PYRAZOLO[1,5-A]PYRIMIDINYLCARBOXAMIDES AND THEIR USE FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS | 2017 |
|
RU2799332C2 |
| AZETIDINYL DIAMIDES AS MONOACYLGLICEROL LIPASE INHIBITORS | 2010 |
|
RU2569298C2 |
| SUBSTITUTED COMPOUNDS OF PYRAZOLE[1,5-a]PYRIMIDINE AS TRK KINASE INHIBITORS | 2010 |
|
RU2584157C2 |
| NOVEL TETRAZOLONE DERIVATIVES | 2014 |
|
RU2664644C2 |
