FIELD: medicine.
SUBSTANCE: method involves carrying out radical operation in combination with intra-operative radiation therapy at a dose of 15 Gray per removed tumor bed and regional metastasis path. The operation combined with intra-operative radiation therapy is done in 3 weeks after finishing polychemotherapy composed of at least 2 courses to reach positive result of tumor reduction more than 75%. Pause between the courses is 3 weeks long. Following scheme is administered: Hemcytabin 1250 mg/m2 in intravenous drop-by-drop introduction during half-an-hour long infusion at the second and the ninth day, Cisplatin 50 mg/m2 is introduced at the first and the eighth day.
EFFECT: stopped progressive tumor development; prevented metastases formation.
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