5-AMINOALKYLPYRAZOLO[4,3-D]PYRIMIDINES Russian patent published in 2006 - IPC C07D487/04 A61K31/519 A61P9/00 A61P15/10 

FIELD: organic chemistry, biochemistry, pharmacy.

SUBSTANCE: invention relates to 5-aminoalkylpyrazolo[4,3-d]pyrimidines of the general formula (I): wherein R¹ and R² are similar or different and represent independently of one another (C₁-C₈)-alkyl group; R³ and R⁴ are similar or different and represent independently of one another (C₁-C₈)-alkoxy-group or halogen atom; R⁵ and R⁶ can be similar or different and represent independently of one another hydrogen atom, linear or branched (C₁-C₈)-alkyl group that can be substituted with one or more hydroxyl groups, (C₁-C₈)-alkoxy-, amino-, mono-(C₁-C₈)-alkyl-amino-, di-[(C₁-C₈)-alkyl]-amino-, N-morpholino- or pyridyl groups or in common with nitrogen atom to which they are bound form unsaturated heterocyclic ring that comprises optionally one or more additional atoms of nitrogen and/or oxygen and substituted with one or more hydroxyl, (C₁-C₈)-alkylol, (C₁-C₆)-oligohydroxyalkyl, amino-, mono-[(C₁-C₈)-alkyl]-amino- or di-[(C₁-C₈)-alkyl]-amino-groups. Proposed compounds inhibit activity of cGMP-phosphodiesterase and can be used in treatment of states of cardiovascular system and for treatment in potency disturbances. Also, invention relates to a medicinal preparation used for inhibition of activity of cGMP-phosphodiesterase based on indicated compounds, a method for preparing compounds of the formula (I) and a method for preparing the medicinal preparation.

EFFECT: improved preparing method, valuable medicinal and biochemical properties of compounds and composition.

7 cl, 15 ex