2-AMINOALKYLTHIENO[2,3-D]PYRIMIDINES, METHOD FOR THEIR PREPARING, MEDICINAL AGENT AND METHOD FOR ITS PREPARING Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, biochemistry, pharmacy.

SUBSTANCE: invention relates to 2-aminomethylthieno[2,3-d]pyrimidines of the general formula (I): wherein R¹ and R² in common with C-atoms with which they are bound form 5-7-membered monounsubstituted cycloalkenyl ring; R³ and R⁴ are similar or different and represent independently of one another (C₁-C₈)-alkoxy-group or halogen atom; R⁵ and R⁶ can be similar or different and represent independently of one another hydrogen atom, linear or branched (C₁-C₈)-alkyl group that can be substituted with one or more hydroxyl, (C₁-C₈)-alkoxy-group, amine, mono-(C₁-C₈-alkyl)-amine or di-(C₁-C₈-alkyl)-amine groups, or in common with nitrogen atom to which they are bound form a heterocyclic ring that comprises optionally one or more additional nitrogen atoms and substituted with one or more hydroxyl, (C₁-C₈)-alkoxy- or (C₁-C₈)-alkylol groups. Compounds elicit the inhibitory effect with respect to activity of phosphodiesterase V and can be used in treatment of cardiovascular system states and in disturbance in the potency injury. Also, invention describes a medicinal preparation based on compounds said, a method for its preparing and a method for preparing compounds.

EFFECT: improved preparing method, valuable medicinal and biochemical properties of compounds.

6 cl, 1 tbl, 16 ex