N-[O-(PARA-PIVALOYLOXYBENZENESULFONYLAMINO)BENZOYL]-GLYCINE MONOSODIUM SALT TETRAHYDRATE SOLUTION AND READY MEDICINAL FORMULATION BASED ON THEREOF Russian patent published in 2006 - IPC A61K31/222 A61K9/08 A61P11/00 

Abstract RU 2272623 C2

FIELD: organic chemistry, pharmacy.

SUBSTANCE: invention relates to a medicinal agent representing solution of the compound N-[O-(p-pivaloyloxybenzenesulfonylamino)benzoyl]glycine of the formula (I):

in common with at least one regulator of pH value chosen from the group consisting of trisodium phosphate hydrate, sodium hydroxide and potassium hydroxide in the amount providing pH 7.0-9.0. Proposed medicinal agent represents injection formulation and designated for treatment of state with the proposed compound that is an inhibitor of enzyme elastase and improves the disease state. Also, invention relates to the ready medicinal formulation of this agent representing the injection formulation prepared by drying and freezing out. Invention provides acceptable solubility and stability of the compound (I) in solution and as a component of ready injection medicinal formulations.

EFFECT: improved and valuable pharmaceutical properties of medicinal formulation.

15 cl, 6 tbl, 1 dwg, 6 ex

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RU 2 272 623 C2

Authors

Takada Akira

Sudokh Masao

Dates

2006-03-27Published

2001-06-28Filed