PHARMACEUTICAL COMPOSITION IN FORM OF LYOPHILISATE WITH COMPLEXANT FOR PREPARATION OF SOLUTION FOR PARENTERAL APPLICATION AND METHOD OF OBTAINING THEREOF Russian patent published in 2015 - IPC A61K9/19 A61K31/44 A61K47/40 

FIELD: medicine.

SUBSTANCE: pharmaceutical composition in form of lyophilisate with complexiant for preparation of solution for parenteral application to treat tuberculosis represents complex in form of prothionamide lyophilisate, which includes in composition water-soluble derivatives of β-cyclodextrine, and in case of addition of pharmaceutically acceptable diluent applicable for intravenous introduction. Pharmaceutical composition is obtained by dissolution of prothionamide substance in pharmaceutically acceptable acid (such as chloromethane, sulphuric, ascorbic, citric, etc.) in equimolar ratio or with up to 20% excess, obtaining complex with cyclodextrine derivative in equimolar ratio or with excess of cyclodextrine derivative up to 20%, sterile filtering of solution, pouring into reservoirs and lyophilic drying. As diluent applied is solution of sodium chloride, glucose and other pharmaceutically acceptable solutions. Finished medication is provided with pH corrector (sodium hydrocarbonate solution).

EFFECT: medication is stable in storage and is applied for preparation of solution for intravenous drip-feed.

11 cl, 2 ex