FIELD: pharmaceuticals.
SUBSTANCE: invention relates to stable lyophilisates containing 5,10-methylene-(6R)-tetrahydrofolic acid or a pharmaceutically acceptable salt thereof and a dicarboxylic acid or salt thereof, as well as methods for their preparation, and the use of such products.
EFFECT: obtaining stable lyophilizates containing 5,10-methylene-(6r)-tetrahydrofolic acid.
10 cl, 1 dwg, 5 tbl, 7 ex
Title |
Year |
Author |
Number |
STABLE PHARMACEUTICAL COMPOSITION OF 5,10-METHYLENTETRAHYDROFOLATE |
2004 |
- Mozer Rudol'F
- Ammann Tomas
|
RU2343923C2 |
METHODS FOR TREATMENT OF COLORECTAL AND METASTATIC COLORECTAL CANCER |
2019 |
- Ganlov, Karin
- Ostberg, Magnus
- Lindberg, Per, L.
- Sunden, Gunnel, E.
- Gustavsson, Bengt
|
RU2779535C2 |
TETRAHYDROFOLATES IN COMBINATION WITH EGFR INHIBITORS |
2013 |
- Gustavsson Bengt
- Karlsson Bern
|
RU2619335C2 |
METHODS FOR INCREASING LEVEL OF 2'-DEOXYURIDINE (DURD) IN PLASMA AND INHIBITING THYMIDYLATE SYNTHASE |
2018 |
- Carlsson, Goran, U.
- Gustavsson, Bengt
- Odin, Elisabeth
- Wettergren, Yvonne
- Vedin, Anders
|
RU2775781C2 |
ADMINISTRATION OF MULTIPLE BOLUSES [6R]-MTHF IN CHEMOTHERAPY BASED ON 5-FLUOROURACIL |
2018 |
- Lindberg Per Lennart
- Sunden Gunnel Elisabeth
- Gustavsson Bengt
- Vedin Anders
|
RU2762596C2 |
APPLICATION OF TETRAHYDROFOLATES OF NATURAL STEREOISOMER FORM AT OBTAINING PHARMACEUTICAL COMPOSITION INDICATED TO AFFECT HOMOCYSTEINE LEVEL, TO MAINTAIN THE PROCESS OF HOMOCYSTEINE REMETHYLATION, IN PARTICULAR |
1998 |
- Mjuller Khans Rudol'F
- Ul'Mann Martin
- Mozer Rudol'F
|
RU2226099C2 |
STABLE CRYSTALLINE SALTS OF TETRAHYDROFOLIC ACID (VARIANTS), METHOD OF THEIR PREPARING AND PHARMACEUTICAL COMPOSITION |
1996 |
- Mjuller Khans Rudol'F
- Ul'Man Martin
- Mozer Rudol'F
- Amman Tomas
|
RU2187508C2 |
STABLE AQUEOUS COMPOSITIONS OF CYCLODEXTRIN INCLUSION COMPOUNDS, COMPOUNDS INCLUDING α-,β- or γ- DEXTRIN OR ITS ALKYL- OR HYDROXYALKYL DERIVATIVES AND (6R)-OR (6S)-5,10- METHYLENE TETRAHYDROFOLIC ACID OR ITS SALT, METHOD OF STABILIZING AQUEOUS SOLUTIONS, AND METHOD OR PREPARING STABLE SOLUTIONS |
1993 |
- Khans Rudol'F Mjuller
- Martin Ul'Mann
- Jozef Konti
|
RU2135519C1 |
5-METHYLTETRAHYDROFOLIC ACID CRYSTALLINE ALKALINE-EARTH SALTS (VARIANTS), METHOD FOR THEIR PREPARING AND COMPOSITION FOR PHARMACEUTICAL AGENTS AND NUTRITION SUPPLEMENTS |
2000 |
- Mjuller Khans Rudol'F
- Mozer Rudol'F
- Ehgger Tomas
|
RU2265605C2 |
STABLE CRYSTALLINE 6(S)- OR 6(R)-TETRAHYDROFOLIC ACID, METHODS OF THEIR PREPARING AND PHARMACEUTICAL COMPOSITION |
1995 |
- Gans Rudol'F Mjuller
- Martin Ul'Mann
- Rudol'F Mozer
- Tomas Amman
|
RU2165422C2 |