METHOD FOR FINDING INDIVIDUAL THERAPY FOR TREATING PATIENTS FOR INTRACEREBRAL MALIGNANT TUMORS Russian patent published in 2006 - IPC A61K31/196 A61P35/00 G01N33/487 

FIELD: medicine.

SUBSTANCE: method involves evaluating neurological status and crude protein and calcium level in cerebrospinal fluid after intrathecally introducing methotrexate in the amount of 5 mg in auto liquor in postoperative period before starting chemotherapy. 5 ml of liquor are taken in a day and methotrexate course dose is selected depending on neurological status and changes in crude protein and calcium level in cerebrospinal fluid in liquor. No changes in neurological status and crude protein and calcium level being observed, methotrexate dose is increased by 20% when compared to the test dose. No changes in neurological status and increased crude protein level by 100% or higher and reduced calcium level by a value between 20% and 40% being observed, methotrexate dose is reduced by 20% when compared to the test dose. Negative changes in neurological status and crude protein being increased more than by 200% and reduced calcium level by more than 40% and reduced crude protein and increased calcium content being observed, chemotherapy course is restricted to already introduced methotrexate test dose.

EFFECT: improved biochemical criteria.

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