WATER-SOLUBLE POLYMERIC ANTIOXIDANT, PLASMA SUBSTITUTE WITH ANTIOXIDANT AND ANTIRADICAL ACTIVITY (VARIANTS) AND METHOD FOR MAINTENANCE ARTERIAL PRESSURE LEVEL AND ANTIOXIDANT PROTECTION PROCESS IN BODY IN ACUTE BLOOD LOSS Russian patent published in 2006 - IPC A61K31/718 A61K31/719 A61K31/721 A61K31/77 A61K9/08 A61P7/08 

FIELD: medicine, transfusion, infusion therapy.

SUBSTANCE: invention proposes antioxidant representing hydroxyethylated starch or pullulan chemically modified with steric-hindranced phenol. Fragment of steric-hindranced phenol represents β-(4-hydroxy-3,5-di-tert.-butylphenyl)-propionyl or β-(4-hydroxy-3,5-di-tert.-butylphenyl)-α-(N-benzoylamino)-acryloyl and its content is from 2 wt.-% up to limit solubility of polymer in water and doesn't exceed 10 wt.-% for modified hydroxyethylated starch and 12 wt.-% for modified pullulan. Plasma substitute showing antioxidant and antiradical activity represents indicated polymeric antioxidant in physiological solution or Ringer-Lock solution in plasma substitute based on the corresponding non-modified polymer. Also, invention describes a method for maintenance the level of arterial pressure and processes of antioxidant protection of body under condition of acute blood loss by using the indicated plasma substitute. As compared with analogs, new plasma substitute shows two kinds of activity: antioxidant and antiradical that are sufficient for operative increase of arterial pressure and its stabilization at the level of physiological norm, and for decreasing amount of free radicals and enhancing antioxidant protection of body in acute massive blood loss.

EFFECT: valuable medicinal properties of agents.

5 cl, 6 tbl, 4 ex