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2 275 934

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IPC

A61K38/31(2006-01-01)

A61P35/00(2006-01-01)

C07K14/655(2006-01-01)

(21) (22)

Application

2003129515/14, 2002-03-06

(24)

Start date

2002-03-06

(22)

Actual filing date

2002-03-06

(45)

Published

2006-05-10

(72)

Inventor

Del'I Uberti Ehttore ChiroDzatelli Marija K'JaraKaller Majkl Devitt

(73)

Holder

Il' Konsortsio Ferrara RicherkeSos'Ete De Konsej De Reshersh Eh D`Applikas'On S'Entifik, S.A.S.

METHOD FOR MODULATING CELL PROLIFERATION OF MEDULLARY THYROID CARCINOMA Russian patent published in 2006 - IPC A61K38/31 A61P35/00 C07K14/655

Abstract RU 2275934 C2

FIELD: medicine.

SUBSTANCE: the present innovation deals with applying agonists of somatostatin receptors in case of thyroid carcinoma and, it also, deals with the method for modulating the rate of cell proliferation of medullary thyroid carcinoma (MTC) due to combined impact upon cells with either one or several agonists of somatostatin receptors of type 2 (SSTR2)or either with one or several agonists of somatostatin receptors of type 5 (SSTR5). Moreover, the mentioned SSTR5 agonist can be represented with D-Phe-Phe-Trp-D-Trp-Lys-Thr-Phe-Thr-NH₂ or its pharmaceutically acceptable salt. The present innovation enables to enhance suppression of MTC cell proliferation due to antagonism between mediated SSTR2 and SSTR5 effects to the proliferation mentioned.

EFFECT: higher efficiency of modulation.

1 cl, 8 dwg, 2 tbl

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RU 2 275 934 C2

Authors

Del'I Uberti Ehttore Chiro

Dzatelli Marija K'Jara

Kaller Majkl Devitt

Dates

2006-05-10—Published

2002-03-06—Filed