CHIMERIC EQUIVALENTS OF LIGANS OF SOMATOSTATIN AND DOPERMINE RECEPTORS, PHARMACEUTICAL COMPOSITIONS BASED ON THEM AND MODALTIES OF SOMATOSTATIN AND/DOPERMINE RECEPTORS Russian patent published in 2008 - IPC C07K14/655 C07D457/00 A61K38/18 A61K31/48 

FIELD: chemistry.

SUBSTANCE: invention pertains to chemeric equivalent of somatostatin, chosen from DPhe- cyclo(Cys- 3ITyr-DTrp-Lys-Val-Cys)-Thr-NH₂, DPhe-cyclo(Cys-3ITyr-DTrp-Lys-Thr-Cys)-Thr-NH₂, DPhe-cyclo(Cys-Tyr-DTrp-Lys-Abu-Cys)-Thr-NH₂, cyclo(Cys-Tyr-DTrp-Lys-Abu-Cys)-Thr-NH₂, DTyr-DTyr-cyclo(Cys-Tyr-DTrp-Lys-Abu-Cys)Thr-NH₂ and DTyr-DTyr-cyclo(Cys-3ITyr-DTrp-Lys-Thr-Cys)Thr-NH₂ and a fragment, joined to a dopermine receptor, chosen from Dop2 , Dop3 , Dop4 and Dop5 . Methods are proposed of obtaining agonistic effect (1) to dopermine receptors; (2) to somatostatin receptors and (3) to dopermine and/or somatostatin receptors, which include introduction of an effective quantity of a chimeric equivalent of a subject in need. A pharmaceutical composition is proposed, which has agonistic effect to dopermine and/or somatostatin receptors, including an effective quantity of a chimeric equivalent.

EFFECT: chimeric equivalent, with agonistic effect to a dopermine and/or somatostatin receptor.

31 cl, 13 ex, 1 tbl