DERIVATIVES OF TETRAHYDROPYRIDINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2006 - IPC C07D217/04 C07D217/16 C07D471/04 A61K31/472 A61P35/00

Abstract RU 2276140 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of tetrahydropyridine of the formula (I): wherein (a) means unsubstituted phenyl group or phenyl group substituted with 1, 2 or 3 substitutes chosen independently among (C₁-C₄)-alkoxy-group, or (b) means unsubstituted indolyl group; R¹and R² are similar or different and mean hydrogen atom, (C₁-C₄)-alkyl or phenyl group; X means alkylene group with a direct chain comprising 5, 6, 7 carbon atoms, and to their pharmaceutically acceptable salts also. Also, invention relates to a pharmaceutical composition possessing the inhibitory activity with respect to HDAC based on these compounds. Invention provides new compounds and pharmaceutical composition based on thereof for aims the stimulation of anti-proliferative effect in warm-blooded animals, such as humans.

EFFECT: valuable medicinal properties of compounds and composition.

4 cl, 1 tbl, 9 ex

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RU 2 276 140 C2

Authors

Georges Gaj

Grossmann Adel'Bert

Mundigl' Olaf

Fon-Der-Sal' Vol'Fgang

Sattel'Kau Tim

Dates

2006-05-10—Published

2001-12-21—Filed