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(19)

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2 269 529

(13)

(51)

IPC

C07D473/06(2006-01-01)

C07D239/54(2006-01-01)

A61K31/47(2006-01-01)

A61K31/52(2006-01-01)

(21) (22)

Application

2002129557/04, 2001-04-05

(24)

Start date

2001-04-05

(22)

Actual filing date

2001-04-05

(45)

Published

2006-02-10

(72)

Inventor

Balaj GurdipKollingvud Stiven PolFehrkherst Robin AlekGomes Sil'Vi FelisiteNehf RetoSandkhehm Dejvid Ehndr'Ju

(73)

Holder

Novartis Ag

DERIVATIVES OF QUINOLINE XANTHINE AND 8-ISOQUINOLINE XANTHINE AS INHIBITORS OF PHOSPHODIESTERASE PDE-5 Russian patent published in 2006 - IPC C07D473/06 C07D239/54 A61K31/47 A61K31/52

Abstract RU 2269529 C2

FIELD: organic chemistry, biochemistry.

SUBSTANCE: invention proposes compound of the formula (1) in free form or as a salt wherein R¹, R², R³, R⁴ and R⁵ have values given in the invention claim. The claimed compounds are selective inhibitors of enzyme PDE-5 and show the high selectivity in inhibition of activity of 3',5'-cycloguanosine monophosphate phosphodiesterase being activity of PDE-5 first of all.

EFFECT: valuable biochemical properties of derivatives.

6 cl, 3 tbl, 87 ex

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RU 2 269 529 C2

Authors

Balaj Gurdip

Kollingvud Stiven Pol

Fehrkherst Robin Alek

Gomes Sil'Vi Felisite

Nehf Reto

Sandkhehm Dejvid Ehndr'Ju

Dates

2006-02-10—Published

2001-04-05—Filed