DERIVATIVES OF TETRALONE AS ANTITUMOR AGENTS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2006 - IPC C07C259/06 A61K31/165 

FIELD: organic chemistry, medicine, oncology, biochemistry, pharmacy.

SUBSTANCE: invention relates to compounds of the formula (I): wherein R1 is chosen from the following order: hydrogen atom, (C₁-C₄)-alkyl, -COOH, -COO-(C₁-C₄)-alkyl; R2, R3, R4 and R5 are chosen independently from the following order: hydrogen, halogen atom, (C₁-C₄)-alkyl-, hydroxy-group, (C₁-C₄)-alkoxy-group; Y means -CH₂-CH₂-; X means alkylene chain comprising from 4 to 10 carbon atoms that is saturated or unsaturated and can comprise one double bond, it can be branched or direct, its enantiomers, and its salts with pharmaceutically acceptable acids and bases. Also, invention relates to a pharmaceutical composition possessing inhibitory effect on histone deacetylase activity and comprising active component as compound of the formula (I) in mixture with pharmaceutically acceptable carrier, excipients or diluting agents. Invention proposes tetralone derivatives possessing antitumor activity.

EFFECT: valuable medicinal properties of derivatives and pharmaceutical composition.

6 cl, 1 tbl, 14 ex