FIELD: chemistry of proteins, medicine.
SUBSTANCE: invention relates to new conjugates of polypeptide factor VII (FVII) or factor VIIa (FVIIa), their preparing and using in medicine, in particular, in treatment of some diseases associated with blood coagulation. Invention proposes a conjugate comprising at least one saccharide molecule bound covalently to the incorporated site of N-glycosylation in vivo wherein polypeptide moiety of conjugate has amino acid sequence that differs from the sequence FVII or FVIIa of "wild" type by 1-15 amino acid residues and given in SEQ ID NO:1. Conjugates of invention possess as minimum at least one improved property as compared with commercially available rFVIIa including increase of the functional half-life period in vivo and/or increase of blood plasma half-life period, and/or decrease of sensitivity to proteolytic degradation.
EFFECT: improved and valuable properties of factors.
16 cl, 1 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| VERSIONS OF GLA DOMAIN OF FACTOR VII OR VIIa | 2004 |
|
RU2373282C2 |
| G-CSG CONJUGATES | 2001 |
|
RU2290411C2 |
| VARIANTS OF GAMMA-INTERFERON POLYPEPTIDE | 2002 |
|
RU2296130C2 |
| INTERFERON-GAMMA CONJUGATES | 2000 |
|
RU2268749C2 |
| DERIVATIVES OF BLOOD COAGULATION FACTORS VII AND VIIA, CONJUGATES AND COMPLEXES CONTAINING THEM AND THEIR APPLICATION | 2012 |
|
RU2620072C2 |
| FACTOR VII CHIMERIC MOLECULES | 2010 |
|
RU2563231C2 |
| MODIFIED FACTOR VII-BASED POLYPEPTIDES AND THEREOF APPLICATION | 2008 |
|
RU2571931C2 |
| CONJUGATE OF FACTOR VII POLYPEPTIDE, METHOD OF OBTAINING IT, ITS APPLICATION AND PHARMACEUTICAL COMPOSITION CONTAINING IT | 2003 |
|
RU2362807C2 |
| MODIFIED COAGULATION FACTOR VIIa WITH EXTENDED HALF-LIFE | 2007 |
|
RU2466141C2 |
| CONJUGATE OF ANTIBODY AND DRUG, COMPOSITIONS BASED ON SAID CONJUGATE AND METHODS OF PRODUCING SAID CONJUGATE | 2015 |
|
RU2728235C2 |
