Patenton — panteon of patents

(19)

RU

(11)

2 362 807

(13)

C2

(51)

IPC

C12N9/64(2006-01-01)

C07K14/745(2006-01-01)

A61K47/48(2006-01-01)

A61K38/36(2006-01-01)

A61P7/02(2006-01-01)

A61P7/04(2006-01-01)

(21) (22)

Application

2005101348/13, 2003-06-20

(24)

Start date

2003-06-20

(22)

Actual filing date

2003-06-20

(45)

Published

2009-07-27

(72)

Inventor

Klausen Nil'S KristianB'Ern SerenBekhrens KarstenGehribehj Patrik Uill'Jam

(73)

Holder

Novo Nordisk Khelt Kehr Ag

CONJUGATE OF FACTOR VII POLYPEPTIDE, METHOD OF OBTAINING IT, ITS APPLICATION AND PHARMACEUTICAL COMPOSITION CONTAINING IT Russian patent published in 2009 - IPC C12N9/64 C07K14/745 A61K47/48 A61K38/36 A61P7/02 A61P7/04 

Abstract RU 2362807 C2

FIELD: biotechnologies.

SUBSTANCE: invention relates to field of biotechnology, namely to obtaining factor VII polypeptides and can be used in medicine. Obtained is conjugate of factor VII polypeptide, including factor VII polypeptide with asparagine-bonded and/or serine-bonded oligosaccharide chains, which include sialic acid or galactose fragments. At least one of oligosaccharide chains is covalently bonded with at least one polymer group representing polyethyleneglycol, which has molecular weight within the range 300-100000 Da. Obtained conjugate of factor VII is used in pharmaceutical composition for treatment of factor VII reactive syndrome.

EFFECT: invention allows to obtain conjugate of factor VII with PEG with set glycolysing character for obtaining homogeneously modified preparation.

22 cl, 1 dwg, 4 ex

Similar patents RU2362807C2

Title Year Author Number
STABILISED SOLID COMPOSITIONS OF VII FACTOR POLYPEPTIDES 2003
  • Ensen Majkl Bekh
  • Khansen Birte Ljukkegor
  • Kornfel'T Troehl'S
 RU2366451C2
METHOD OF OBTAINING, METHOD OF PURIFICATION AND METHOD OF STABILISATION OF FACTOR VII, IX AND X POLYPEPTIDES 2004
  • Krarup Janus
  • Persson Ehgon
 RU2364626C2
LIQUID WATER PHARMACEUTICAL COMPOSITION CONTAINING FACTOR VII POLYPEPTIDE 2004
  • Jensen Mikhael' Bekh
  • Petersen Anders Klarskov
  • Bouler Ehndrju Nejl
 RU2388460C2
POLYPEPTIDE OF VII HUMAN COAGULATION FACTOR, PRODUCTION AND APPLICATION 2002
  • Persson Ehgon
  • Olsen Ole Vilsted
 RU2325401C2
METHOD OF REDUCING DIMER CONTENT IN COMPOSITION CONTAINING FACTOR VII POLYPEPTIDE BY HEAT TREATMENT 2008
  • Krarup Janus
 RU2483079C2
POLYPEPTYDE OF HEMOSTASIS FACTOR VII, PRODUCTION AND APPLICATION 2001
  • Persson Ehgon
  • Ol'Sen Ole Vil'Sted
 RU2326126C2
LIQUID COMPOSITION OF FACTOR VII POLYPEPTIDES 2002
  • Khansen Birte Ljukkegor
  • Ensen Mikaehl' Bekh
  • Kornfel'T Troehl'S
 RU2357751C2
PHARMACEUTICAL COMPOSITION COMPRISING FACTOR VII POLYPEPTIDES AND PAI-1 POLYPEPTIDES 2002
  • Rejker Rasmus
 RU2304980C2
PHARMACEUTICAL COMPOSITION CONTAINING FACTOR VII POLYPEPTIDES AND FACTOR XI POLYPEPTIDES 2002
  • Rejker Rasmus
 RU2298416C2
COMBINED APPLICATION OF FACTOR VII POLYPEPTIDES AND FACTOR VIII POLYPEPTIDES 2002
  • Knudsen Ens B'Erre
  • Khedner Ulla
  • Rejk'Er Rasmus
 RU2311923C2

RU 2 362 807 C2

Authors

Klausen Nil'S Kristian

B'Ern Seren

Bekhrens Karsten

Gehribehj Patrik Uill'Jam

Dates

2009-07-27—Published

2003-06-20—Filed

download Download PDF read Similar patents