FIELD: biotechnologies.
SUBSTANCE: invention relates to field of biotechnology, namely to obtaining factor VII polypeptides and can be used in medicine. Obtained is conjugate of factor VII polypeptide, including factor VII polypeptide with asparagine-bonded and/or serine-bonded oligosaccharide chains, which include sialic acid or galactose fragments. At least one of oligosaccharide chains is covalently bonded with at least one polymer group representing polyethyleneglycol, which has molecular weight within the range 300-100000 Da. Obtained conjugate of factor VII is used in pharmaceutical composition for treatment of factor VII reactive syndrome.
EFFECT: invention allows to obtain conjugate of factor VII with PEG with set glycolysing character for obtaining homogeneously modified preparation.
22 cl, 1 dwg, 4 ex
Authors
Dates
2009-07-27—Published
2003-06-20—Filed