FIELD: pharmaceuticals.
SUBSTANCE: invention relates to compounds of formula (I)-(VI) and/or (A)-(HI) or any subgenus thereof or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof. The invention relates to a compound having the structure of formula (AI), or to a pharmaceutically acceptable salt or stereoisomer thereof, where C is a 5–7-membered monocyclic heteroaryl containing 1, 2 or 3 heteroatoms selected from O, S or N as ring member; X is a bond, -(CR5R6)t - or -NR7; Y is a bond, -CH2 -, -C(CH3)H-, -O-, -S-, -NH-, -NCH3 - or -N(COCH3)-; Z is a bond, -CH2 -, -O- or -NH-; W is a bond, -CH2-, -C(CH3)H-, -C(=O)-, -N(R7)CO- or -CONR7-; V is -CH2 — and L is halogen, -NH2 or -CF3; or V is -CH2CH2 — and L is halogen or -NH2; R1 and R2 are each independently hydrogen, halogen, -CN, -CF3, methyl or -CONH2; R3 is selected from -CN, C1-C3 alkoxy, -CF3, C1-C3 alkyl, C2-C3 alkenyl, C2-C3 alkynyl, -S(C1-C3 alkyl), -SO2(C1-C3 alkyl), -NH2, -(C1-C3 alkyl) NH2, -NHSO2CH3, -NHSO2CF3, -N(CH3)SO2CH3, -NHSO2CH2CH3, -N(CH3)SO2CH2CH3, -CH2NHSO2CH3, -CH2N(CH3)SO2CH3, -SO2NH2, -CONH2, -CON(C1-C3 alkyl)2, -CONH(C1-C3 alkyl), -NHCO(C1-C3 alkyl), -N(CH3)COO(C1-C3 alkyl), -NHCO(C1-C3 alkyl) or -N(CH3)COO(C1-C3 alkyl); R5 and R6 are each independently hydrogen, halogen, -OH, or C1-C3 alkyl; R7 is H or C1-C6 alkyl; n1 and n2 are each independently 0, 1 or 2; n3 is 1, 2, 3, 4 or 5; and t is 0, 1, or 2. The invention also relates to a pharmaceutical composition having an androgen receptor (AR) inhibitory activity based on the said compound.
EFFECT: obtaining new compounds and a pharmaceutical composition based on them which can be used in medicine as effective agents for the treatment of prostate cancer.
21 cl, 7 dwg, 4 tbl, 38 ex
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