FIELD: medicine, gastroenterology, pharmacy.
SUBSTANCE: invention describes solid pharmaceutical compositions used in treatment of gastroenteric disorders. The composition comprises omeprazole as a proton pump inhibitor wherein at least part of drug is not covered by an enterosoluble envelope and sodium hydrocarbonate as a buffering agent. The composition is made as a chewing tablet. By the second variant the composition comprises omeprazole that is partially is not covered by an enterosoluble envelope, sodium hydrocarbonate as a buffering agent and at least one disintegrating agent and/or lubricant. In oral administration in a patient of indicated pharmaceutical compositions the effective amount of omeprazole in absorbed directly by patient stomach for immediate and effective treatment of disorders associated with gastric acid. New medicinal formulations of omeprazole are suitable for preparing and provide its rapid absorption and availability of the omeprazole preparation for a definite group of patients that are unable to swallow solid medicinal formulations.
EFFECT: improved and valuable medicinal and pharmaceutical properties of formulations.
19 cl, 4 dwg, 5 tbl, 13 ex
