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2 279 425

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(51)

IPC

C07D211/46(2006-01-01)

A61K31/445(2006-01-01)

A61P3/00(2006-01-01)

A61P25/00(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2003124756/04, 2002-01-11

(24)

Start date

2002-01-11

(22)

Actual filing date

2002-01-11

(45)

Published

2006-07-10

(72)

Inventor

Battehrs Tehrens D.Duehk Rejmond A.Flit DzhordzhOrchard Majkl GlenPlehtt Frehnsis Mehri

(73)

Holder

Oksford Glikosajensiz Kej) LtdDze Chensehller, Mastehrs Ehnd Skolars Of Dze Juniversiti Of Oksford

DERIVATIVES OF PIPERIDINE, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2006 - IPC C07D211/46 A61K31/445 A61P3/00 A61P25/00 A61P35/00

Abstract RU 2279425 C2

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of piperidine of the general formula (I): wherein R represents (C₁-C₁₆)-alkyl or (C₁-C₁₀)-alkylphenyl wherein phenyl is optionally substituted with -OR¹ wherein R¹ represents (C₁-C₆)-alkyl, or their pharmaceutically acceptable salts. These compounds possess inhibitory activity with respect to enzyme glucosylceramide synthase and can be used in medicine in treatment of diseases caused by accumulation of glycolipid.

EFFECT: improved preparing method, valuable medicinal and biochemical properties of derivatives.

15 cl, 2 dwg, 2 tbl, 15 ex

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RU 2 279 425 C2

Authors

Battehrs Tehrens D.

Duehk Rejmond A.

Flit Dzhordzh

Orchard Majkl Glen

Plehtt Frehnsis Mehri

Dates

2006-07-10—Published

2002-01-11—Filed