DERIVATIVES OF BENZOXAZEPINE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND THEIR USING AS AGONISTS OF AMPA RECEPTOR Russian patent published in 2006 - IPC C07D498/04 C07D515/04 A61K31/553 A61K31/554 A61P25/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of benzoxazepine and describes derivative of benzoxazepine of the general formula (I): wherein X represents -CO or -SO₂; R¹, R², R³ and R⁴ are chosen independently from hydrogen atom (H), (C₁-C₄)-alkyl, (C₁-C₄)-alkoxy-group, (C₁-C₄)-alkyloxy-(C₁-C₄)-alkyl, -CF₃, halogen atom, nitro-group, cyano-group, -NR⁸R⁹, -NR⁸COR¹⁰ and -CONR⁸R⁹; R⁵, R⁶ and R⁷ represent independently hydrogen atom (H) or (C₁-C₄)-alkyl; R⁸ and R⁹ represent independently hydrogen atom (H) or (C₁-C₄)-alkyl; or R⁸ and R⁹ in common with nitrogen atom to which they are bound form 5- or 6-membered saturated heterocyclic ring comprising optionally the additional heteroatom chosen from oxygen atom (O), sulfur atom (S) or the group -NR¹¹; R¹⁰ represents (C₁-C₄)-alkyl; R¹¹ represents (C₁-C₄)-alkyl; A represents residue of 4-7-membered saturated heterocyclic ring comprising optionally oxygen atom wherein ring is substituted optionally with 1-3 substitutes chosen from (C₁-C₄)-alkyl, (C₁-C₄)-alkoxy-, hydroxy-group, halogen atom and oxo-group, or to its pharmaceutically acceptable salt under condition that compounds of the formula (I) are excluded wherein X represents -CO, and each among R¹-R⁷ represents hydrogen atom (H), and A represents -(CH₂)₃ or -(CH₂)₄; compounds of the formula (I) wherein X represents -CO; R¹ represents hydrogen atom (H); R² represents methyl (CH₃); each among R³-R⁷ represents hydrogen atom (H), and A represents -(CH₂)₃; compounds of the formula (I) wherein X represents -CO; R¹ and R² represent hydrogen atom (H); R³ represents methyl; each among R⁴-R⁷ represents hydrogen atom (H), and A represents -(CH₂)₃; compounds of the formula (I) wherein X represents -CO; each among R¹-R³ represents hydrogen atom (H); R⁴ represents methyl; each among R⁵-R⁷ represents hydrogen atom (H), and A represents -(CH₂)₃, and compounds of the formula (I) wherein X represents -CO; each among R¹-R⁴ represents hydrogen atom (H); R⁵ represents methyl; R⁶ and R⁷ represent hydrogen atom (H), and A represents -(CH₂)₃. Also, invention describes pharmaceutical compositions comprising indicated derivatives and using these benzoxazepine derivatives in treatment of neurological diseases and psychotic disorders sensitive to enhancing responses mediated by AMPA receptors in the central nervous system. Invention provides preparing new compounds possessing the useful biological properties.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

8 cl, 1 tbl, 31 ex