NOVEL CONDENSED PYRIDINE DERIVATIVES USED AS C-MET TYROSINE KINASE INHIBITORS Russian patent published in 2017 - IPC C07D471/04 C07D498/04 C07D513/04 A61K31/4353 A61P35/00 

FIELD: chemistry.

SUBSTANCE: compounds have c-Met inhibiting properties. In the formula I

B is absent, represents O, S, OCH₂ or SCH₂; each of the R₁, R₂, R₃ and R₄ independently represents hydrogen, halogen, unsubstituted C_1-6alkyl, C_1-6alkyl substituted by hydroxyl or 3-6 membered heterocyclyl with one heteroatom selected from N; carbamoyl; R₁ and R₂ or R₃ and R₄ form = O or cyclopropyl together; A represents N or CH; n equals 0, 1 or 2; each of the R₅ independently represents halogen or unsubstituted C_1-6alkyl; Z is NHR₆ or is represented by formula II

,

where each of the R₁₈ and R₁₉ independently represents an unsubstituted C_1-8alkyl or phenyl substituted by halogen; R₆ is represented by formula

,

when R₆ represented by formula VII, B represents O, S,OCH₂ or SCH₂; B₁ represents

where each of the Q₁ independently represents C(R₇)₂; B₂ represents NHQ₂, and Q₂ represents phenyl substituted by halogen; Q₃ represents hydrogen or phenyl substituted by halogen; each of the R₇, R₈, R₉ and R₁₀ independently represents hydrogen or phenyl substituted by halogen. The invention also relates to a pharmaceutical composition, to use of pharmaceutical composition to prepare a medical agent; to use of a compound to prepare a medical agent.

EFFECT: obtaining novel condensed derivatives of formula I, having a high inhibitory activity on c-Met.

36 cl, 2 tbl, 73 ex