FIBRIN/FIBRINOGEN-BINDING CONJUGATE Russian patent published in 2006 - IPC A61K38/48 A61K39/00 A61K47/48 

FIELD: biotechnology, medicine.

SUBSTANCE: claimed conjugate contains fibrin/fibrinogen-binding fragment bound to pharmaceutically active agent directly or via intermediate fragment trapping said agent, such as antibody. Conjugate may represent recombinant fused protein comprising C-terminal domain of VEGF₁₆₅, fused with substance for wound healing, such as leptin.

EFFECT: conjugate capable of depot formation for prolonged elimination of pharmaceutically active agent from fibrin gout.

15 cl, 13 dwg, 8 ex