PHARMACEUTICAL COMPOSITIONS FOR ORAL AND TOPICAL USING Russian patent published in 2006 - IPC A61K47/14 A61K9/10 A61K9/48 A61K38/13 A61K31/337 

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to a pharmaceutical composition that comprises the following components, %: hydrophobic active component representing cyclosporine and/or taxane, 0.1-30.0; one or some gelatinizing substances chosen from fatty acid polyglycerol esters, 0.1-60.0; one or some gel-forming substances chosen from fatty acid polyglycerol esters and/or unsaturated fatty acids, 0.1-60.0; one or some substances chosen from triglyceride macrogol glycerol esters, partial glycerides or fatty acids, or fatty acid macrogol esters, 1.0-60.0, and ethanol, 5.0-30.0. In dilution with water the composition forms dispersion of polymorphous nonspherical gel particles having size from 0.2 to 500 mcm. Invention provides acceptable bioavailability of therapeutically active cyclosporines and taxanes showing difficult solubility in water.

EFFECT: improved and valuable properties of pharmaceutical compositions.

13 cl, 8 dwg, 1 tbl, 20 ex