FIELD: medicine, pharmaceutical technology, pharmacy.
SUBSTANCE: invention relates to a method for preparing methyluracil-base preparation representing stimulating agent of leucopoiesis in form of a tablet. The proposed method is carried out by mixing an active substance that is taken in the therapeutically permitted amount with accessory additives followed by granulation and tableting. Lactose and starch taken in the ratio 2:1 are used as accessory additives. After mixing all components the prepared mass is wetted firstly with 5% solution of medium-molecular polyvinylpyrrolidone followed by rewetting with 10% solution of polyvinylpyrrolidone wherein the total amount of mean-molecular polyvinylpyrrolidone is 5-5.5% of the total weight. The wet mass is granulated and dried at temperature 45-55°C and vacuum value 0.7-0.9 kgf/cm2 up to the residual moisture 3.5-4.0%. Then 8-10% of granules of their total amount are powdered with aerosil and calcium stearate taken in equal parts in the amount 0.5-0.8% of the total amount of the preparation followed by addition of other amount of granulate and tableting the prepared mixture. Invention provides simplified technology and simultaneous creature of a simple and available formulation of the medicinal agent as a tablet, enhanced strength of tablet and simultaneous rapid breaking up tablet in water, enhanced stability of tablet at storage.
EFFECT: improved preparing method, improved and valuable medicinal and pharmaceutical properties of preparation.
2 tbl, 1 ex
