FIELD: organic chemistry, chemical technology, medicine.
SUBSTANCE: invention relates to a new 2-amino-4-acetyl-7-bromo-8b-hydroxy-3a,8b-dihydrothiazolo[5,4-b]indole hydrobromide of the formula (1) 
that is able to protect body against hypoxia and liver against poisoning with carbon tetrachloride. The melting point of this compound is 266-267°C (with decomposition). The compound is synthesized from 1-acetyl-5-bromo-3-indolinone and elemental bromine in dioxane medium followed by addition of thiourea in isopropyl alcohol.
EFFECT: valuable medicinal properties of compound.
2 tbl, 1 ex
| Title |
Year |
Author |
Number |
| 2-AMINO-4-ACETYL-7-BROMO-8-HYDROXY-3,8-DIHYDROXYTIAZOLO[5,4-b]INDOLE FOR LIVER PROTECTION FROM POISONING WITH CARBON TETRACHLORIDE |
2004 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
|
RU2286348C2 |
| USE OF 2-AMINO-7-BROMO-4-ACETYLAZO[5,4-b]INDOL TO PROTECT ORGANISM AGAINST HYPERBARIC AND HEMATIC HYPOXIA AND/OR LIVER AGAINST CARBON TETRACHLORIDE POISONING |
2004 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
- Gavrev Aleksej Ivanovich
|
RU2318828C2 |
| 2-AMINO-4-ACETYL-8 -HYDROXY-3,8-DIHYDROTHIAZOLO[5,4-D]INDOLE HYDROBROMIDE PROTECTING AGAINST HYPOXIA |
2003 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
|
RU2281096C2 |
| USING 2-AMINO-7-BROMO-4-ACETYLTHIAZOLO[5,4-b]INDOLE HYDROBROMIDE FOR LIVER PROTECTION AGAINST POISONING WITH CARBON TETRACHLORIDE AND/OR LUNG TOXIC EDEMA IN PROPHYLACTIC DOSE |
2004 |
- Marysheva Vera Vasil'Evna
- Torkunov Pavel Anatol'Evich
- Shabanov Petr Dmitrievich
|
RU2309742C2 |
| USING 2-AMINO-4-ACETYLTHIAZOLO[5,4-b]INDOLE FOR LIVER PROTECTION AGAINST POISONING WITH CARBON TETRACHLORIDE |
2004 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
|
RU2309743C2 |
| HYDROBROMIDE OF 1-ACETYL-2-ISOTHIOUREIDO-3-INDOLINONE PROTECTED LIVER AGAINST POISONING OF CARBON TETRACHLORIDE |
1991 |
- Velezheva V.S.
- Mel'Man A.I.
- Tomchin A.B.
- Marysheva V.V.
- Smirnov A.V.
- Okovityj S.V.
- Gajvoronskaja V.V.
|
RU2009127C1 |
| 2-AMINO-4-ACETYLTHIAZOLO[5,4-B]INDOLE HYDROBROMIDE PROTECTING LIVER AGAINST POISONING WITH CARBON TETRACHLORIDE AND A METHOD OF ITS SYNTHESIS |
1992 |
- Velezheva V.S.
- Mel'Man A.I.
- Tomchin A.B.
- Smirnov A.V.
- Okovityj S.V.
- Gajvoronskaja V.V.
|
RU2076867C1 |
| APPLICATION OF HYDROBROMIDE 2-AMINO-4-ACETYL-8-HYDROXY-3,8-DIHYDROTHYAZOLE [5,4-b] INDOLE FOR WORKING CAPACITY INCREASE |
2007 |
- Marysheva Vera Vasil'Evna
- Gavrev Aleksej Ivanovich
- Shabanov Petr Dmitrievich
|
RU2361585C2 |
| 2-METHYLTHIOPYRIMIDO[4,5-b]INDOLE PROTECTING LIVER FROM POISONING WITH CARBON TETRACHLORIDE |
2004 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
|
RU2300534C2 |
| APPLICATION OF 4-ACETYL-7-BROMINE-8b-HYDROXY-3a,8b-DIHYDROIMIDAZO {4,5-b}INDOLE-2-THIONE FOR PROTECTION OF ORGANISM AGAINST IMPACT OF HYPOBARIC AND GEMIC HYPOXIA |
2005 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
|
RU2335286C2 |
