FIELD: organic chemistry, medicine, hepatology.
SUBSTANCE: invention relates to using 2-methylthiopyrimido[4,5-b]indole of the formula (1): 
showing melting point at 243°C (with decomposition) and value LD50 > 1000 mg/kg used in liver protection from poisoning with carbon tetrachloride. Proposed compound exceeds activity of the "Essentiale" as a comparison preparation.
EFFECT: valuable medicinal property of compound, enhanced effectiveness.
1 tbl
| Title |
Year |
Author |
Number |
| USING 2-AMINO-4-ACETYLTHIAZOLO[5,4-b]INDOLE FOR LIVER PROTECTION AGAINST POISONING WITH CARBON TETRACHLORIDE |
2004 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
|
RU2309743C2 |
| 2-AMINO-4-ACETYL-7-BROMO-8-HYDROXY-3,8-DIHYDROXYTIAZOLO[5,4-b]INDOLE FOR LIVER PROTECTION FROM POISONING WITH CARBON TETRACHLORIDE |
2004 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
|
RU2286348C2 |
| 2-AMINO-4-ACETYL-7-BROMO-8-HYDROXY-3,8-DIHYDROTHIAZOLO[5,4-b]INDOLE HYDROBROMIDE PROTECTING BODY AGAINST HYPOXIA AND LIVER AGAINST POISONING WITH CARBON TETRACHLORIDE |
2004 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
|
RU2281949C2 |
| USING 2-AMINO-7-BROMO-4-ACETYLTHIAZOLO[5,4-b]INDOLE HYDROBROMIDE FOR LIVER PROTECTION AGAINST POISONING WITH CARBON TETRACHLORIDE AND/OR LUNG TOXIC EDEMA IN PROPHYLACTIC DOSE |
2004 |
- Marysheva Vera Vasil'Evna
- Torkunov Pavel Anatol'Evich
- Shabanov Petr Dmitrievich
|
RU2309742C2 |
| USE OF 2-AMINO-7-BROMO-4-ACETYLAZO[5,4-b]INDOL TO PROTECT ORGANISM AGAINST HYPERBARIC AND HEMATIC HYPOXIA AND/OR LIVER AGAINST CARBON TETRACHLORIDE POISONING |
2004 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
- Gavrev Aleksej Ivanovich
|
RU2318828C2 |
| 4-ACETYL-3-BENZYL-2-METHYLTHIOIMIDAZO (4,5 ) INDOLE PROTECTING LIVER AGAINST POISONING OF CARBON TETRACHLORIDE |
1991 |
- Velezheva V.S.
- Mel'Man A.I.
- Tomchin A.B.
- Okovityj S.V.
- Smirnov A.V.
- Gajvoronskaja V.V.
|
RU2009141C1 |
| HEPATOPROTECTING AGENT |
1996 |
- Vitik Andrej Zinov'Evich
- Gazaliev Arstan Maulenovich
- Guljaev Aleksandr Evgen'Evich
|
RU2156130C1 |
| HYDROBROMIDE OF 1-ACETYL-2-ISOTHIOUREIDO-3-INDOLINONE PROTECTED LIVER AGAINST POISONING OF CARBON TETRACHLORIDE |
1991 |
- Velezheva V.S.
- Mel'Man A.I.
- Tomchin A.B.
- Marysheva V.V.
- Smirnov A.V.
- Okovityj S.V.
- Gajvoronskaja V.V.
|
RU2009127C1 |
| 2-AMINO-4-ACETYLTHIAZOLO[5,4-B]INDOLE HYDROBROMIDE PROTECTING LIVER AGAINST POISONING WITH CARBON TETRACHLORIDE AND A METHOD OF ITS SYNTHESIS |
1992 |
- Velezheva V.S.
- Mel'Man A.I.
- Tomchin A.B.
- Smirnov A.V.
- Okovityj S.V.
- Gajvoronskaja V.V.
|
RU2076867C1 |
| 3-[3-(4-METHYLPIPERAZINE-1-YL)-PROPYLTHIO]-1,2,4-TRIAZINO- [5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION |
1991 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
|
SU1829358A1 |
