FIELD: organic chemistry, pharmacy.
SUBSTANCE: invention relates to novel derivatives of diphenylazethidinone of the formula (I): 
wherein R1 means hydrogen atom; R2 means -(CH2)0-1-NH-C(O)-(C3-C12)-alkylene-C(O)NH-L; R3 and R6 mean hydrogen atom; R4 and R5 mean atoms F, Cl, Br, J; L means compound of the formula: 
wherein Rx, Ry and Rz mean hydrogen atom (H), and to their pharmaceutically acceptable salts also. Compounds of the formula (I) elicit cholesterol-declining activity and can be used in medicine.
EFFECT: improved preparing method, valuable medicinal properties of compounds and composition.
4 cl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF DIPHENYLAZETHIDINONE, MEDICINAL AGENTS COMPRISING THESE COMPOUNDS AND THEIR USING | 2001 |
|
RU2275370C2 |
| CYCLIC-SUBSTITUTED DIPHENYLAZETHIDINONES, THEIR USING FOR PREPARING MEDICINE AGENT | 2003 |
|
RU2315754C2 |
| CATION-SUBSTITUTED DIPHENYLAZETHIDINONES, METHOD FOR THEIR PREPARING, MEDICINAL AGENTS COMPRISING THESE COMPOUNDS AND THEIR USING | 2003 |
|
RU2315753C2 |
| NOVEL 1,2-DIPHENYLAZEAZETHIDINONES, THEIR USING IN TREATMENT OF LIPID METABOLISM DISORDER, MEDICINAL AGENT AND METHOD FOR ITS PREPARING | 2001 |
|
RU2286985C2 |
| DIPHENYLAZETHIDINONES SUBSTITUTED WITH ACIDIC GROUPS, METHOD FOR THEIR PREPARING, MEDICINAL AGENT COMPRISING THEREOF AND THEIR USING | 2003 |
|
RU2287522C2 |
| NEW DIPHENYLASETYDIONE WITH IMPROVED PHYSIOLOGICAL PROPERTIES, METHODS OF ITS PRODUCTION, MEDICAL PRODUCTS CONTAINING THESE COMPOUNDS AND APPLICATION THEREOF | 2004 |
|
RU2334737C2 |
| CONDENSED TRIAZOLAMINES AS P2X7 MODULATORS | 2010 |
|
RU2533122C2 |
| CARBOXAMIDE COMPOUNDS AND USE THEREOF AS CALPAIN INHIBITORS | 2010 |
|
RU2567392C2 |
| AZOLE DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHBITORS | 2006 |
|
RU2414458C2 |
| NOVEL COMPOUNDS AS CATHEPSIN INHIBITORS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, THEIR USING AND METHOD FOR THEIR PREPARING | 2002 |
|
RU2316546C2 |
