CYCLIC-SUBSTITUTED DIPHENYLAZETHIDINONES, THEIR USING FOR PREPARING MEDICINE AGENT Russian patent published in 2008 - IPC C07D205/08 C07D403/12 C07D413/12 A61K31/397 A61P3/06 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes cyclic-substituted diphenylazethidinones of the formula (I): wherein each radical among R1, R2, R3, R4, R5 and R6 means independently of one another (C₁-C₃₀)-alkylene-(LAG)_n wherein n = 1-2; one or two carbon atoms in alkylene residue are replaced with phenyl or piperazinyl residues or (C₃-C₁₀)-cycloalkyl residue; one or some carbon atoms in alkylene residue can be replaced with -S(O)_n wherein n = 2; -O-, -(C=O)- or -NH-; hydrogen atom (H), fluorine atom (F), chlorine atom (Cl), bromine atom (Br), iodine atom (J), O-(C₁-C₆)-alkyl; (LAG)_n means mono- or tricyclic trialkyl ammoniumalkyl residue, -(CH₂)₀-SO₃H, -(CH₂)₀-COOH, -(CH₂)₀-C(=NH)(NH₂), and pharmaceutically acceptable salts also. Proposed compounds decrease the serum cholesterol content. Also, invention describes using these compounds for preparing a medicinal agent used in treatment of lipid metabolism disorders.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

7 cl, 1 tbl, 22 ex