CATION-SUBSTITUTED DIPHENYLAZETHIDINONES, METHOD FOR THEIR PREPARING, MEDICINAL AGENTS COMPRISING THESE COMPOUNDS AND THEIR USING Russian patent published in 2008 - IPC C07D205/08 A61K31/397 A61P3/06 C07D207/20 C07D241/06 C07D265/28 C07D487/08 

Abstract RU 2315753 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes compounds of the formula (I): wherein R1-R5 mean independently of one another (C0-C30)-alkylene-(LAG)n wherein n = 1, and one or some C-atoms in alkylene residue can be replaced for -O-, -(C=O)-, -C=CH-, -NH-, hydrogen atom (H), fluorine atom (F), chlorine atom (Cl), bromine atom (Br), iodine atom (J), (C1-C6)-alkyl, O-(C1-C6)-alkyl; (LAG)n means mono- or tricyclic trialkyl ammoniumalkyl residue or LAG can mean -(CH2)0-10-C(=NH)(NH2), -(CH2)0-10-C(=NH)(NHOH) or -NR7-C(=NR8)(NR9R10). Also, invention describes a medicinal agent for decreasing the serum cholesterol content and a method for its preparing. Proposed compounds are useful, for example, as hypolipidemic agents.

EFFECT: improved methods of synthesis and preparing, valuable medicinal properties of compounds and pharmaceutical composition.

6 cl, 1 tbl, 34 ex

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Authors

Jene Gerkhard

Frik Vendelin

Flor Shtefani

Lindenshmidt Andreas

Glombik Khajner

Kramer Verner

Khojer Khubert

Shefer Khans-Ljudvig

Dates

2008-01-27Published

2003-06-04Filed